The Clinical Impact of Daptomycin Non-susceptible Enterococcus Bacteremia in Hematologic Malignancy
نویسندگان
چکیده
800. Improving Definitive Therapy Among Patients with Methicillin-resistant Staphylococcus aureus Bloodstream Infections: Predictors of Early Therapeutic Switch to Linezolid or Daptomycin Marin Schweizer, PhD; Kelly Richardson, PhD; Mary Vaughan Sarrazin, PhD; Michael Jones, PhD; Daniel Livorsi, MD, MSc; Rajeshwari Nair, MBBS, PhD; Michihiko Goto, MD, MSCI; Bruce Alexander, PharmD; Brice Beck, MA and Eli Perencevich, MD, MS, FIDSA, FSHEA; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, Iowa City VA Health Care System, Iowa City, Iowa, Iowa City VA Medical Center, Iowa City, Iowa, University of Iowa, Iowa City, Iowa, Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
منابع مشابه
Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible Enterococcus faecium harboring LiaSR substitutions.
High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 µg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium ...
متن کاملVancomycin-resistant Enterococcus bacteremia: an evaluation of treatment with linezolid or daptomycin.
BACKGROUND Due to high rates of resistance and a limited number of efficacious antimicrobials for vancomycin-resistant Enterococcus (VRE), appropriate antibiotic selection is vital to treatment success. The purpose of this study was to assess clinical and microbiologic outcomes associated with the use of linezolid or daptomycin in the treatment of VRE bacteremia. METHODS A retrospective analy...
متن کاملReal-World Treatment of Enterococcal Infections with Daptomycin: Insights from a Large European Registry (EU-CORE)
INTRODUCTION Evolution of antibacterial resistance in pathogenic enterococcal strains poses a growing therapeutic challenge. Daptomycin, a cyclic lipopeptide, exhibits broad antibiotic activity against Gram-positive bacteria. METHODS The European Cubicin(®) Outcomes Registry and Experience, a multicenter, retrospective, non-interventional study, recorded clinical outcomes following daptomycin...
متن کاملPrevalence and detection of mixed-population enterococcal bacteremia.
Mixed-population (heterogeneous) enterococcal bacteremia (MEB) is rarely reported. Based on one occasion in which Vitek2 missed a vancomycin-resistant subpopulation isolated from a patient, we developed a simple method to detect this subpopulation and determined MEB frequency. The four patients presented here had either Enterococcus faecium or Enterococcus faecalis bacteremia caused by both van...
متن کاملClinical Features, Risk Factors and Outcomes of Bacteremia due to Enterococci with High-Level Gentamicin Resistance: Comparison with Bacteremia due to Enterococci without High-Level Gentamicin Resistance
High-level gentamicin resistance (HLGR) in enterococci has increased since the 1980s, but the clinical significance of the resistance and its impact on outcome have not been established. One hundred and thirty-six patients with bacteremia caused by enterococci with HLGR (HLGR group) were compared with 79 patients with bacteremia caused by enterococci without HLGR (non-HLGR group). Hematologic m...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017